Michaela Eckert

Full member: June 2007 - May 2010

Dissertation title: Antidepressants-effects on ionic currents in neuronal and cardiac cells.
Abstract: Two-pore-domain potassium channels (K2P) are widely expressed in the central nervous system as well as in the heart. They function as potassium background currents, thereby regulating cellular excitability. K2P-channels comprises 15 members devided into six subfamilies: TWIK, TALK, TASK, TREK, THIK and TRESK.
Recently it has been demonstrated that knockout of TREK-1, a member of the K2P-family, leads to an non-depressive phenotype in mice. I investigate the effects of clinically used antidepressants on different members of the K2P family expressed both in heart and brain to elucidate their role in the treatment of mood disorders accompanied by unwanted cardiac side effects. 

Principal investigator:

Prof. Dr. Erhard Wischmeyer
Department of Physiology II, Röntgenring 9, 97070 Würzburg

https://www.med.uni-wuerzburg.de/physiologie/neurophysiologie/mitarbeiter/mitarbeiter-des-lehrstuhls/wischmeyer-erhard/prof-erhard-wischmeyer/

Current position:

Trainee by Winicker Norimed Clinical Research

https://www.winicker-norimed.com/

https://www.med.uni-wuerzburg.de/physiologie/physiologieII/