Magdalena Weidner, M.Sc.
Klinik und Poliklinik für Psychiatrie und Psychotherapie
Füchsleinstraße 15
97080 Würzburg
Department of Psychiatry and Neuropsychology
School for Mental Health and Neuroscience
Maastricht University
Universiteitssingel 40
6229 ER Maastricht
| Phone | +49 931 201 77 540 |
| Fax | +49 931 201 77 252 |
| Magdalena Weidner |
Department:
Department of Psychiatry (Psychobiologie), University of Würzburg
Project:
Title: Effect of stress exposure on epigenetic programming with regard to emotional behavior.
Abstract: Today it is well known that not only genetic predisposition but also the environment is crucial in the aetiology of psychiatric disorders. However, the question of how the environment is able to influence the phenotypic outcome of the genetic setup in the long run is not really understood. One environmental factor that has been shown to be critically involved in this regard is stress. Numerous publications discuss especially the effects of early life stress exposure on stress axis development and consequently emotional reactivity. Thereby epigenetics represent a promising mediator of environmental signals. Epigenetic modifications occur throughout the whole lifetime and represent an additional dynamic regulatory entity that is capable of translating environmental cues such as stress into molecular and consequently behavioural changes.
In our study we focus especially on the effects of early and later life stress in interaction with diverse serotonin system modifications on emotional reactivity and the molecular correlates of observed behavioural changes.
Principal investigator:
Related projects/members:
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Previous studies:
Bachelor and Master Degree, Julius-Maximilians-Universität, Würzburg
Thesis:
Bachelor Thesis: Quantitative estimation of adult neurogenesis in mice deficient for the serotonin transporter, which went through two different learning tasks
Master Thesis: Effect of prenatal stress on epigenetic programming and gene expression in serotonin transporter deficient mice
Publications:
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